Enzymes are nature’s catalysts. They are biomolecules that help facilitate chemical reactions so that they can occur under mild conditions. At PNNL we study enzymes in order to understand the functional principles they use to regulate the chemical reactions. This knowledge allows us to transfer some of these principles to synthetic catalysts that are more efficient, cheaper and cleaner and can be used in industrial processes. In this presentation, I will give an overview of a few enzymes that are relevant to chemical transformation for energy applications and present some the findings that have revealed some of their unique properties.